AM Pharma
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About us

AM-Pharma’s purpose is to save and improve the lives of patients confronted with severe medical conditions. Our initial focus is sepsis-associated acute kidney injury, the cause of death for hundreds of thousands of people hospitalized each year. Our proprietary compound, ilofotase alfa, has the potential to become the first treatment for sepsis-associated acute kidney injury and is now in a global pivotal Phase III clinical trial. We are a dedicated team driven to bring treatment options to severely ill patients, their families and acute care professionals.

AM-Pharma is developing a treatment for sepsis and acute kidney injury, that could be lifesaving

AM-Pharma, founded in 2001 and based in Utrecht, the Netherlands, has entered into late-stage clinical development for its treatment for sepsis-associated acute kidney injury (SA-AKI): recombinant human alkaline phosphatase therapeutic. The company is focused on the successful execution of its Phase III REVIVAL pivotal trial while continuing to build an organization committed to using its insight and knowledge for other severe medical conditions including other kidney disease, sepsis and organ injury-related indications.

OUR MISSION

At AM-Pharma, we strive to improve the quality of life for patients with severe medical conditions, initially focusing on saving the lives of patients with sepsis-associated acute kidney injury (SA-AKI).

Read more about these promising clinical outcomes

AM-PHARMA’S CORE VALUES

Collaboration

At AM-Pharma we work together in a constructive, collaborative and team-oriented way, towards achieving the company objectives without losing sight of our own objectives. We put the common interest of the company and the patient above our own individual interest.

Quality orientation

We set high standards regarding the quality of our materials, processes, documentation and collaborations, the staff are motivated to deliver excellence whilst also working to continually improve the quality of our work.

Accountability

We are fully accountable for the things that are in our power and control while working on the goals of the organization. We have an obligation to proactively report, explain and justify the things we do. We accept responsibility for our performance and we are transparent about the results of our work.

Resilience

We understand how to cope effectively with setbacks and obstacles and overcome hurdles on our way to reach our common goal. We stay committed to agreed objectives and company culture despite resistance while having the strength to adjust our plans when necessary. We are tolerant to stress and we deal effectively with criticism and resistance, building on our own strength.

MANAGEMENT TEAM

Erik van den Berg

MSc, MBA Chief Executive Officer

Juliane Bernholz

PhD Chief Operating Officer

Maarten Kraan

MD, PhD Chief Medical Officer

Lars Boesgaard

MBA Chief Finance Officer

Laetitia Szaller

General Counsel & VP Business Development

Wolfgang Meder

PhD VP Regulatory Affairs & Quality Management

Jacques Arend

MD VP Clinical Development

Kristie Bass

BSc VP Clinical Operations

Teun van de Laar

PhD VP Manufacturing & Supply Chain Management

Martijn Negen

MSc, MBA VP Commercial Strategy

Alexander Bastian

MBA, VP Value & Market Access

SUPERVISORY BOARD

Mark Altmeyer, MBA - Chairman of the Board

Prior to joining AM-Pharma’s Supervisory Board, Mark Altmeyer was founder, President and Chief Executive Officer at Arvelle Therapeutics, in addition to serving as Executive Director of Arvelle’s Board of Directors. At Arvelle, he led the development of the company until its acquisition by Angelini for USD 1 billion. In advance of that transaction, he established Arvelle’s global headquarters in Switzerland, secured USD 200 million initial funding and built the European team to over 100 employees in under two years. Before Arvelle, Mark served as President and Chief Commercial Officer at Axovant Sciences, where he was responsible for establishing Axovant’s global commercial capabilities and launch preparations for various pipeline products. Earlier in his career, Mark served as President and CEO at Otsuka America Pharmaceutical, leading the transformation into a successful commercial organization, doubling total revenues from USD 2.5 billion to nearly 5 billion in five years. Mark held senior commercial and business development positions at Bristol-Myers Squibb, Cetus Corporation and Bristol Labs in the United States. He holds an MBA from Harvard Graduate School of Business and a BA in economics from Middlebury College.  

Martijn Kleijwegt, MSc

Martijn Kleijwegt, is a Managing Partner and Founder at LSP and a pioneer in the European life sciences arena.  He was instrumental in the successes of Prosensa (NL, IPO in 2013, sold to Biomarin for €548 million in 2015), Movetis (BEL, IPO in 2009, sold to Shire for €428 million in 2010), Crucell (NL, IPO in 2000, sold to Johnson & Johnson for €1.75 billion in 2011), Rhein Biotech (NL, IPO in 1999, sold to Berna Biotech for €279 million in 2002), and Qiagen (GER, IPO in 1996, valued 30 June 2017 at €6.6 billion).

After starting his career at Philips, he gained extensive experience in the life sciences sector as General Partner of Euroventures Benelux, one of the first venture funds in Europe with life sciences in its investment scope.  Martijn led the life sciences investment strategy and built the Euroventures Life Sciences (ELS) fund.  In 1998, Martijn founded LSP and together with the other general partners built it into what it is today.  Martijn currently represents LSP on the supervisory boards of Kiadis Pharma (NL), OxThera (SE), Orphazyme (DK), Pharvaris (GER), Arvelle therapeutics (NL/CH) and Eloxx Pharmaceuticals (USA/IS).

He holds a Master’s degree in Economics from Amsterdam University.

Felice Verduyn-van Weegen, MSc, MBS

Felice Verduyn-van Weegen, is an Investment Manager at LSP. She joined the company in 2015.

Felice serves on the Boards of Pharvaris (GER) and OxThera (SE) as an Observer and was a driving force behind the investments of Arvelle Therapeutics (NL/CH), Orphazyme (DK), Eloxx Pharmaceuticals (USA/IS), Simplify Medical (USA) and G-Therapeutics (NL).

Prior to joining LSP, Felice was a consultant at McKinsey & Company with a primary focus on healthcare. Before McKinsey, she was a neuroscientist and statistical geneticist, working with the prestigious complex traits genetics group at the Broad Institute and Harvard Medical School in Cambridge, USA. Prior to that, she worked at the department of Biological Psychology at the VU University in Amsterdam, the Netherlands. Felice authored a number of scientific articles in prestigious journals.

Felice was awarded a Bachelor’s degree in Biological Psychology and a Master’s degree in Neuroscience from the VU University, Amsterdam. In addition, she was awarded an MBA from Columbia Business School, New York USA.

Raphaël Wisniewski, MSc

Raphaël Wisniewski is a Managing Partner at Andera Partners (formerly Edmond de Rothschild Investment Partners).

Raphaël serves as a Director on the Board of ReViral, MedDay Pharmaceuticals, Artios Pharma, Dynacure, Grey Wolf, Axonics Modulation and as an observer on the Boards of Poxel and Enyo. Previously, he worked in Healthcare Corporate Finance at Goldman Sachs starting at Salomon Smith Barney. He was also in the Finance Departments of Health in London and in the Department of General Healthcare in London, the private hospital group.

Raphaël is a graduate of the Ecole des Hautes Etudes Commerciales, Paris, and holds a Master’s degree in Economics and Finance from the Institut d’Etudes Politiques (IEP), Paris.

Geert-Jan Mulder, MD

Geert-Jan Mulder is a Managing Partner at Forbion.

He currently serves on the Board of several Forbion portfolio companies. In addition, Geert-Jan led the firm’s successful investment in bluebirdbio, which went public in 2013, where he supported the company in clinical development and served as the chairman for several years. Other investments include Acorda Therapeutics, which went public in 2006 and where he was part of the AMPYRA® (dalfampridine) board panel to evaluate a new regulatory endpoint in Multiple Sclerosis, PanGenetics B.V., Transave, and Exosome Diagnostics. In addition, he is a co-author of several Forbion and Forbion portfolio related scientific publications.

Geert-Jan received his MD from the University of Utrecht (NL) and spent two years as a clinician in Obstetrics and Gynecology at the University Medical Center of Utrecht (UMC).

Rémi Droller, MSc

Rémi Droller is a Managing Partner of Kurma Partners.

Prior to that, he held positions at CDC Innovation from 2000 to 2003 and at AGF Private Equity (now Idinvest Partners) from 2003 to 2010, where he was in charge of developing the life sciences investment activity. Rémi serves on the Board of Dynacure (France), ImCheck Therapeutics (France), Orphazyme (Denmark – listed on the Copenhagen Stock Exchange), Oxthera (France) and Pharvaris (the Netherlands).

Rémi has a Master’s degree in Molecular Biology (Paris VI University) and a Master’s degree in Finance and Innovation Management (AgroPariTech).

Joël Jean-Mairet, PhD (Board Observer)

Joël is managing partner and co-founder of Ysios Capital.

Previously, he co-founded Glycart Biotechnology in 2001 and was its CEO until it was successfully sold to F. Hoffmann La-Roche four years later. Glycart Biotechnology was the originator of the anti-CD20 antibody – obinituzumab/Gazyva®, the first breakthrough designated drug approved by the FDA for B-CLL. He holds an MS in Biotechnology and a PhD from the Swiss Federal Institute of Technology (ETH) in Zurich.

Joël is currently on the boards of directors of Adcendo, LAVA Therapeutics (Nasdaq: LVTX), Ona Therapeutics, SpliceBio and Executive Chairman of Inbiomotion. He has been Chairman of the board of Cellerix/Tigenix (now Takeda), board member of Aura Biosciences (Nasdaq: AURA) and Sanifit Therapeutics (now Vifor Pharma), and board observer at Biovex (now Amgen). Joël has earned numerous awards, including the Wall Street Journal’s Europe Innovation Award in 2001.

Rita Jain, MD

Next to a board member at AM-Pharma, Rita also serves as a member of the Board of Directors for Chemocentryx. Previously, Rita served as the Senior Vice President and Chief Medical Officer of Akebia Therapeutics, Inc and had management roles at AbbVie, Inc and prior to the split of AbbVie from Abbott, at Abbott Laboratories. Most recently, as Vice President of Men’s and Women’s Health and Metabolic Development at AbbVie, Inc., she held various positions including Divisional Vice President at Abbott Laboratories. Rita also led activities in pain, respiratory, cystic fibrosis development, arthritis, inflammation and pain. She was a faculty member at North Shore University Hospital in New York, with an academic appointment as Assistant Professor of Medicine, New York University School of Medicine.

Rita received her Bachelor’s degree in Biology from LIU/C.W. Post and her MD from the State University of New York at Stony Brook School of Medicine. She completed her medical training in Internal Medicine at Staten Island University Hospital followed by a Fellowship in Rheumatology at North Shore University Hospital and a Clinical Research Fellowship at the University of Texas Southwestern Medical Center, Dallas.

Careers

AM-Pharma is a clinical stage biopharmaceutical company based in Utrecht, the Netherlands.

Our mission is to save and improve the lifes of patients confronted with severe medical conditions by initially focusing on sepsis-associated acute kidney injury, the cause of death for hundreds of thousands of people hospitalized each year. Join us in fighting these devastating conditions.

INTERESTED IN A CAREER AT AM-PHARMA?

Details of current vacancies – if any – are listed on this page. To apply, please send your CV and cover letter, stating the title of the position you are applying for, to hr@am-pharma.com.

We have been made aware that a malicious party unaffiliated with AM-Pharma is conducting fake recruitment activities including issuing fake offer letters, with a view to illegally obtaining copies of the applicant’s ID. Please do not respond to such requests. Please be aware that career opportunities are published only through AM-Pharma’s official communication channels. We will never ask for payments or fees from job applicants, and applicants will only be contacted by an AM-Pharma team member through an official AM-Pharma email address ending in @am-pharma.com. Interviews will never be conducted via Telegram, Fleep, Google Hangouts, What’sApp, or other social media platforms or apps.

AM-Pharma does work with established recruitment agencies that may conduct interviews by phone, but partners affiliated with AM-Pharma will under no circumstance require copies of applicants’ personal ID, nor conduct interviews through social media or mobile apps. In case of doubt or if you suspect any fraudulent activity, please report it immediately,  hr@am-pharma.com

Office Manager

We are currently looking for an

Office Manager (32-40 hours)

About the Role

At AM-Pharma, the Office Manager is a real “multi-tasker” with great organizing, coordinating  and supporting skills. You are good at facilitating planning, running an accurate administration and you perform well in a group of highly skilled professionals, even in times of pressure or high workload. You ensure that all supportive tasks in the office are structured efficiently, run smoothly and are well organized and people can rely on your support. The team currently exists of 30 employees and 15 consultants and is expanding very quickly.

Your responsibilities include

  • Organizing business trips
  • Complex calendar management which requires a proactive and structured approach
  • Organization of online and offline meetings and company events
  • Contract administration for our legal department
  • First point of contact for all facility tasks
  • Ensure all office supplies and groceries are always well-stocked
  • Answering the phone / welcoming guests / processing post mail
  • Administrative support for HR
  • Replace Executive Assistant in case of absence
  • Taking part in the Company Emergency Response Team (BHV)

Job Requirements include

  • Secretarial education / Office Management at MBO+ (post-secondary vocational education) or Bachelor level
  • With your great problem-solving skills you like to work for a team of highly skilled professionals of different nationalities
  • You have excellent proficiency in Dutch and English, both spoken and in writing
  • You can deal with peaks in the planning and a high workload
  • You can work independently, and you know how to be service oriented and assertive at the same time
  • You can easily switch from simple to complex tasks and vice versa
  • You have a well-developed sense of responsibility, are service-oriented and work accurately
  • You have working experience with Office 365 for business (Outlook, Sharepoint, Teams, Powerpoint, Word, Excel etc)

AM-Pharma company culture
The company culture of AM-Pharma is built on four important competences: Collaboration, Quality orientation, Accountability and Resilience.  At AM-Pharma we work together in a constructive, collaborative and team-oriented way, towards achieving the company objectives without losing sight of our own objectives. We put the common interest of the company above our own individual interest.
We set high standards regarding the quality of our materials, processes, documentation and collaborations, the staff are motivated to deliver excellence whilst also working to continually improve the quality of our work. We are fully accountable for the things that are in our power and control while working on the goals of the organization. We have an obligation to proactively report, explain and justify the things we do. We accept responsibility for our performance and we are transparent about the results of our work.  Finally, we understand how to cope effectively with setbacks and obstacles and overcome hurdles on our way to reach our common goal. We stay committed to agreed objectives and company culture despite resistance while having the strength to adjust our plans when necessary. We are tolerant to stress and we deal effectively with criticism and resistance, building on our own strength.

Remuneration
Salary at market level

Company pension scheme (premium is 100% paid by employer)

Mobile phone

1st class public transportation or travel allowance of Euro 0,19 per km

 

Start date
As soon as possible, but no later than 1 August 2022

Location
AM-Pharma is located in the brand new World Trade Center Utrecht Central, next to Utrecht Central Railway Station in the lively business heart of Utrecht, close to Amsterdam and Schiphol Amsterdam Airport. For this position, you are allowed to work from home 1 day a week.

To apply
Please send your CV and cover letter, stating the title of the position you are applying for,
to hr@am-pharma.com

Clinical Scientist

To support the expansion of AM-Pharma’s business, we are currently looking for a

Clinical Scientist

About the role
At AM-Pharma, we are actively conducting a global Phase III program treating critically ill patients with acute kidney injury in partnership with a clinical research organization. In addition, we are in the process of starting clinical research in a second and third indication and this will likely be executed in the same format. We have also started our preparations for commercial readiness that includes the build of the appropriate organization. As Clinical Scientist, you will be asked to support our global drug development activities by:

  • Providing scientific, clinical and operational input to clinical development studies with emphasis on protocol-specific and clinical data monitoring activities; this includes (but not limited to) protocol and study design, data review, interpretation and presentation
  • Elaborating, reviewing and updating clinical documents including SAP, protocol/amendments, medical review documents, training material, informed consent documents, study reports, PK reports, protocol deviation list, input to data management activities (e.g. electronic data capture, data review plan, case report forms) etc.
  • Working with the cross-functional clinical trial teams on design, execution and monitoring of clinical trials as well as data interpretation and communication
  • Supporting our Clinical Trial Site Liaisons (EU and US) with clinical input
  • Working closely with medical on medical data reviews, coordinating DMC meetings and TSC meetings.
  • Supports publications/presentations as needed

What we expect
We expect our Clinical Scientist to have:

  • PhD degree in Biomedical (Pharmacology, Biology, Chemical Engineering etc.)
  • Relevant experience in clinical development and providing clinical scientific advice
  • Excellent interpersonal, verbal and written communication skills
  • Ability to plan, organize, prioritize and execute multiple tasks within assigned objectives
  • Ability to work effectively in an international matrix team and value the importance of teamwork
  • You can deal with peaks in the planning, a high workload and the ad-hoc and fast paced nature of biotech
  • Fluent knowledge of English (written and oral)
  • Advanced knowledge of MS Office (Word, PowerPoint, Excel)

 

AM-Pharma company culture
The company culture of AM-Pharma is built on four important competences: Collaboration, Quality orientation, Accountability and Resilience.  At AM-Pharma we work together in a constructive, collaborative and team-oriented way, towards achieving the company objectives without losing sight of our own objectives. We put the common interest of the company above our own individual interest.
We set high standards regarding the quality of our materials, processes, documentation and collaborations, the staff are motivated to deliver excellence whilst also working to continually improve the quality of our work. We are fully accountable for the things that are in our power and control while working on the goals of the organization. We have an obligation to proactively report, explain and justify the things we do. We accept responsibility for our performance and we are transparent about the results of our work.  Finally, we understand how to cope effectively with setbacks and obstacles and overcome hurdles on our way to reach our common goal. We stay committed to agreed objectives and company culture despite resistance while having the strength to adjust our plans when necessary. We are tolerant to stress and we deal effectively with criticism and resistance, building on our own strength.

Remuneration
Salary at market level, depending on education and working experience
Company pension scheme (100% contribution by employer)
Mobile phone
Full reimbursement of public transportation or travel allowance of Euro 0,19 per km

Start date
As soon as possible

Location
AM-Pharma is currently located in the brand-new World Trade Center Utrecht Central, adjacent to Utrecht Central Railway Station in the lively business heart of Utrecht, close to Amsterdam and Schiphol Amsterdam Airport.

To apply
Please send your CV and cover letter, stating the title of the position you are applying for,
to hr@am-pharma.com

Consultant Clinical Trial Site Liaison - Australia (0.5 FTE)

About the role
The Consultant Clinical Trial Site Liaison (CTSL) Australia is responsible for building, managing and supporting site relationships on behalf of the AM-Pharma organization within Australia. This is a position at Director level and will report directly to the VP Clinical Operations. He/she ensures efficient and high-quality recruitment into our clinical studies through interaction with study personnel. She/he will elaborate high quality presentations of scientific data in various settings, including advisory boards, investigator meetings, to enhance product/disease state knowledge. He/she has significant experience facilitating strong relationships with the external scientific and medical community and has a track-record of best practices. He/she engages with Key Opinion Leaders, provides medical support for the brand plans, supports the development strategy and initiatives and programs. He/she runs this position from our offices in Utrecht and will have significant travel mainly to study sites.

What we expect
We expect our Consultant Clinical Trial Site Liaison Australia to:

  • Bring a minimum of 10 years of experience in Medical Affairs or Clinical Operations in a GCP/FDA regulated pharmaceutical company; have experience in supporting Phase-III programs.
  • Be an MD (PhD) or hold a Master’s degree in Life Sciences with Pharma industry experience (preferably having previous experience in the CTSL or MSL role).
  • Have a thorough understanding of applicable federal and state regulatory requirements for field‐based scientific personnel and to keep a successful track record of compliance.
  • Have experience/expertise in interpretation of scientific data, market research, competitive intelligence tools, drug information systems, and developing medical educational strategies.
  • Have outstanding written and verbal communication/listening and presentation skills.
  • Have previous success translating/tailoring complex scientific concepts into simple language for targeted audiences.
  • Keep demonstrated problem solving abilities and strong organizational skills.
  • Bring a history of great collaboration/teamwork; have a reputation for successful partnering with internal and external stakeholders, including medical opinion leaders, large group practices, medical directors and MCO professionals.
  • Have a good understanding of clinical development and commercial environment.
  • Have the ability to work successfully in a small organization.
  • Be pragmatic, solution-oriented thinker who possesses a “can do” and” whatever it takes” attitude, coupled with excellent organizational and communication skills (verbal, written, listening, conveying messages).
  • Have strong interpersonal skills with the ability to motivate and influence others, negotiate during situational conflict, and establish the best forward path in the face of competing points of view.
  • Be proficient with Veeva and Microsoft Office; in depth Word, PowerPoint & Excel skills.
  • Have the ability to travel (60%) within Australia.
  • Be available for AM-Pharma on part-time basis (0.5FTE).

AM-Pharma company culture
The company culture of AM-Pharma is built on four important competences: Collaboration, Quality orientation, Accountability and Resilience.  At AM-Pharma we work together in a constructive, collaborative and team-oriented way, towards achieving the company objectives without losing sight of our own objectives. We put the common interest of the company above our own individual interest.
We set high standards regarding the quality of our materials, processes, documentation and collaborations; staff are motivated to deliver excellence whilst also working to continually improve the quality of our work. We are fully accountable for the things that are in our power and control while working on the goals of the organization. We have an obligation to proactively report, explain and justify the things we do. We accept responsibility for our performance and we are transparent about the results of our work.  Finally, we understand how to cope effectively with setbacks and obstacles and overcome hurdles on our way to reach our common goal. We stay committed to agreed objectives and company culture despite resistance while having the strength to adjust our plans when necessary. We are tolerant to stress and we deal effectively with criticism and resistance, building on our own strength.

Remuneration
At market level.

Start date
We expect the candidate to start its employment latest as of Q2 2022.

Location
AM-Pharma main location is in World Trade Center Utrecht Central, adjacent to Utrecht Central Railway Station in the lively business heart of Utrecht, close to Amsterdam and Schiphol Amsterdam Airport. For this consultant role, we would expect candidates to work remotely.

Sr. Quality Officer

About the role
At AM-Pharma, we are actively conducting global Phase III programs treating critically ill patients with acute kidney injury in partnership with a clinical research organization. As Sr. Quality Officer, you support the Sr. Director Quality Management with the design, development and execution of Quality policies and guidelines, the approval of quality documents, review and improvement of the GCP and GMP compliance of the company and with professionalizing the quality systems of the company. You are responsible for

  • Reviewing, revising and approving Quality documents through our document change process;
  • Reviewing and approving of change requests, deviation reports, complaints and CAPA’s;
  • Reviewing and approving of clinical trial reports in case of deviations and complaints;
  • Keeping track of change requests, deviations and CAPA’s and closing and archiving of completed documents;
  • Reviewing and approving of validation, stability and transfer protocols and reports;
  • Conducting audits at vendors, on systems and analytical methods;
  • Reviewing and approving of batch documentation, QC results and reports of findings to the QP of AM-Pharma;
  • (Co-)executor of audits; executing internal and vendor audits and reporting about the results;
  • Setting up systems for mock-recalls and assist in execution;
  • Reporting of quality KPI’s and other information for management review purposes;
  • Assist with regulatory inspections;
  • Designing and improving AM-Pharma’s quality system, including writing new protocols, improving existing protocols and the design and maintenance of databases;
  • Providing advice and training to colleagues and peers about GCP, GMP and basic quality systems.

What we expect
We expect our Sr. Quality Officer to keep a Bachelor or Master degree, a completed education in Pharmacy, Bio-pharmaceutical Science, Biochemistry or comparable. The Sr. Quality Officer has

  • A minimum of 5 years of experience in a Quality management department in a biopharmaceutical environment;
  • Proven knowledge about Quality systems in GMP, and preferably in GCP.
  • Understands the dynamics of Clinical Operations including Regulatory and CMC processes and supply chain;
  • Ability to work with MS Office software (including Excel, Word, PowerPoint);
  • Proficiency in written and spoken English;
  • Ability to plan, organize, prioritize and execute multiple tasks within assigned objectives;
  • Ability to work effectively in an international matrix team and value the importance of teamwork;
  • Ability to deal with peaks in the planning, a high workload and the ad-hoc and fast paced nature of biotech;

Remuneration
Salary at market level, depending on education and working experience
Company pension scheme (100% contribution by employer)
Mobile phone and laptop
Full reimbursement of public transportation or travel allowance of Euro 0,19 per km

Start date
As soon as possible

Location
AM-Pharma is currently located in the brand-new World Trade Center Utrecht Central, adjacent to Utrecht Central Railway Station in the lively business heart of Utrecht, close to Amsterdam and Schiphol Amsterdam Airport.

How to apply
Please send your CV and cover letter, stating the title of the position you are applying for,
to hr@am-pharma.com

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